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鎼滅储
鎼� 绱�
楂樼瓑鏁欒偛闋�(l菒ng)鍩熸暩(sh霉)瀛楀寲缍滃悎鏈嶅嫏(w霉)骞宠嚭(t谩i)
鎼� 绱�
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STAR-T鍜孴CR-T绱�(x矛)鑳炲厤鐤不鐧傛妧琛�(sh霉)
1.鐥涢粸(di菐n)鍟忛
寰�(f霉)鐧�(f膩)杞�(zhu菐n)绉荤殑鏅氭湡鐧岀櫏鎮ｈ€呯己涔忔湁鏁堢殑娌荤檪鎵嬫銆佺敓瀛樻湡鏈涗綆锛岃揩鍒囬渶瑕佹柊鐨勬不鐧傛柟娉曘€備綔鐐烘柊鑸堢殑绮炬簴(zh菙n)閱�(y墨)瀛�(xu茅)娌荤檪鎵嬫锛屼互CAR-T绱�(x矛)鑳炴不鐧傜偤浠ｈ〃鐨勫厤鐤檪娉曞緱鍒颁簡蹇€熺櫦(f膩)灞曪紝浣嗗洜鍏舵不鐧傝不(f猫i)鐢ㄦ槀璨淬€侀仼鎳�(y墨ng)鐧ラ檺鍒跺拰瀹夊叏鎬х瓑鍟忛闄愬埗浜嗗叾鑷ㄥ簥寤ｆ硾鎳�(y墨ng)鐢ㄣ€�
2.瑙ｆ焙鏂规
鏈爡(xi脿ng)鎴愭灉鐨勬牳蹇冩妧琛�(sh霉)涔嬩竴STAR锛圫yntheticTcellreceptorandAntigenReceptor锛�-T锛屽嵆“鍚堟垚T绱�(x矛)鑳炲彈楂斿拰鎶楀師鍙楅珨”锛岄噰鐢ㄤ簡鍓�(chu脿ng)鏂板瀷T绱�(x矛)鑳炲彈楂�-鎶楅珨寰�(f霉)鍚堢墿绲�(ji茅)妲�(g貌u)锛屽叿鏈夊ぉ鐒堕洐闈堕粸(di菐n)鐨勭祼(ji茅)妲�(g貌u)鍎�(y艒u)鍕�(sh矛)锛岀敱浜庢暣鍚堜簡鎶楀師璀�(sh铆)鍒ュ崁(q奴)鑸嘥CR鎭掑畾鍗€(q奴)鍙婂叾娲诲寲閫氳矾锛屽洜姝ゅ叿鏈夎Κ鍜屽姏楂樸€佺壒鐣版€у挤(qi谩ng)鐨勭壒鎬э紝鍦ㄧ窗(x矛)鑳炴不鐧傝娑茬槫鍜屽(sh铆)楂旂槫鏂瑰悜鍏锋湁鑹ソ鐨勮嚚搴婃噳(y墨ng)鐢ㄥ墠鏅拰寤ｉ棅鐨勭敘(ch菐n)鍝佸競鍫�(ch菐ng)绌洪枔銆傛澶栵紝鍙︿竴闋�(xi脿ng)鎴愭灉娑夊強鍎�(y艒u)鍖栫殑TCR-T鎶€琛�(sh霉)锛岀獊鐮翠簡鍌崇当(t菕ng)TCR-T鐗瑰畾鍔熻兘鎬у簭鍒楃殑鐛插彇闆ｉ鍜岄嚌灏�(du矛)涓嶅悓鎮ｈ€匟LA鍨嬬殑TCR鍒嗗瀷闆ｉ锛屼娇TCR-T绱�(x矛)鑳炴不鐧傜殑鐢�(ch菐n)妤�(y猫)鍖栨噳(y墨ng)鐢ㄦ垚鐐哄彲鑳姐€�
鏈爡(xi脿ng)鎴愭灉闋�(y霉)鏈熷熀浜嶴TAR-T鍜孴CR-T鎶€琛�(sh霉)鐢�(ch菐n)鍑洪嚌灏�(du矛)琛€娑茬槫銆佸(sh铆)楂旂槫銆佺梾姣掓€ф劅鏌撶瓑鐤剧梾鐩搁棞(gu膩n)鐨勭窗(x矛)鑳炴不鐧傜敘(ch菐n)鍝併€�
娓呰彲澶у(xu茅)
2022-06-06
STAR-T鍜孴CR-T绱�(x矛)鑳炲厤鐤不鐧傛妧琛�(sh霉)
1.鐥涢粸(di菐n)鍟忛
寰�(f霉)鐧�(f膩)杞�(zhu菐n)绉荤殑鏅氭湡鐧岀櫏鎮ｈ€呯己涔忔湁鏁堢殑娌荤檪鎵嬫銆佺敓瀛樻湡鏈涗綆锛岃揩鍒囬渶瑕佹柊鐨勬不鐧傛柟娉曘€備綔鐐烘柊鑸堢殑绮炬簴(zh菙n)閱�(y墨)瀛�(xu茅)娌荤檪鎵嬫锛屼互CAR-T绱�(x矛)鑳炴不鐧傜偤浠ｈ〃鐨勫厤鐤檪娉曞緱鍒颁簡蹇€熺櫦(f膩)灞曪紝浣嗗洜鍏舵不鐧傝不(f猫i)鐢ㄦ槀璨淬€侀仼鎳�(y墨ng)鐧ラ檺鍒跺拰瀹夊叏鎬х瓑鍟忛闄愬埗浜嗗叾鑷ㄥ簥寤ｆ硾鎳�(y墨ng)鐢ㄣ€�
2.瑙ｆ焙鏂规
鏈爡(xi脿ng)鎴愭灉鐨勬牳蹇冩妧琛�(sh霉)涔嬩竴STAR锛圫yntheticTcellreceptorandAntigenReceptor锛�-T锛屽嵆“鍚堟垚T绱�(x矛)鑳炲彈楂斿拰鎶楀師鍙楅珨”锛岄噰鐢ㄤ簡鍓�(chu脿ng)鏂板瀷T绱�(x矛)鑳炲彈楂�-鎶楅珨寰�(f霉)鍚堢墿绲�(ji茅)妲�(g貌u)锛屽叿鏈夊ぉ鐒堕洐闈堕粸(di菐n)鐨勭祼(ji茅)妲�(g貌u)鍎�(y艒u)鍕�(sh矛)锛岀敱浜庢暣鍚堜簡鎶楀師璀�(sh铆)鍒ュ崁(q奴)鑸嘥CR鎭掑畾鍗€(q奴)鍙婂叾娲诲寲閫氳矾锛屽洜姝ゅ叿鏈夎Κ鍜屽姏楂樸€佺壒鐣版€у挤(qi谩ng)鐨勭壒鎬э紝鍦ㄧ窗(x矛)鑳炴不鐧傝娑茬槫鍜屽(sh铆)楂旂槫鏂瑰悜鍏锋湁鑹ソ鐨勮嚚搴婃噳(y墨ng)鐢ㄥ墠鏅拰寤ｉ棅鐨勭敘(ch菐n)鍝佸競鍫�(ch菐ng)绌洪枔銆傛澶栵紝鍙︿竴闋�(xi脿ng)鎴愭灉娑夊強鍎�(y艒u)鍖栫殑TCR-T鎶€琛�(sh霉)锛岀獊鐮翠簡鍌崇当(t菕ng)TCR-T鐗瑰畾鍔熻兘鎬у簭鍒楃殑鐛插彇闆ｉ鍜岄嚌灏�(du矛)涓嶅悓鎮ｈ€匟LA鍨嬬殑TCR鍒嗗瀷闆ｉ锛屼娇TCR-T绱�(x矛)鑳炴不鐧傜殑鐢�(ch菐n)妤�(y猫)鍖栨噳(y墨ng)鐢ㄦ垚鐐哄彲鑳姐€�
鏈爡(xi脿ng)鎴愭灉闋�(y霉)鏈熷熀浜嶴TAR-T鍜孴CR-T鎶€琛�(sh霉)鐢�(ch菐n)鍑洪嚌灏�(du矛)琛€娑茬槫銆佸(sh铆)楂旂槫銆佺梾姣掓€ф劅鏌撶瓑鐤剧梾鐩搁棞(gu膩n)鐨勭窗(x矛)鑳炴不鐧傜敘(ch菐n)鍝併€�
娓呰彲澶у(xu茅)
2022-07-04
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鐓ょう浜曚笅鍣存伎鏂欎笂鏂欒缃�
铻烘棆杓搁€佹(j墨)涓€绔彃鍏ヨ鏈夊櫞婕挎贩鍑濆湡鏂欑殑绀﹁粖鍏�(n猫i)锛屽彟涓€绔敱姘ｅ嫊(d貌ng)棣仈(d谩)椹�(q奴)鍕�(d貌ng)鍥炶綁(zhu菐n)瀵�(sh铆)鐝�(xi脿n)灏囧櫞婕挎贩鍑濆湡鏂欒几閫佸埌涓€鍋�(c猫)鐨勫櫞婕挎(j墨)鏂欐枟涓€傝垏鐝�(xi脿n)鏈夊櫞婕挎贩鍑濆湡鏂欎笂鏂欒缃浉姣旓紝瑭茶缃叿鏈夌祼(ji茅)妲�(g貌u)杓曞阀锛屾搷浣滅啊(ji菐n)渚匡紝涓婃枡鍙潬绛夌壒榛�(di菐n)銆�
瀹夊窘鐞嗗伐澶у(xu茅)
2021-04-11
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鍩轰簬PLC鐓ょう浜曚笅鐖嗙牬浠跨湡绯荤当(t菕ng)
鏈郴绲�(t菕ng)鏄熀浜嶱LC瑷�(sh猫)瑷�(j矛)鍑虹殑涓€濂楄兘浠跨湡鐓ょう浜曚笅鐖嗙牬宸ヤ綔鐠�(hu谩n)澧冿紝骞舵牴鎿�(j霉)浠跨湡鐠�(hu谩n)澧冩焙绛栧嚭鏈€浣崇殑鐖嗙牬鏂规锛屽悓鏅�(sh铆)浠跨湡绯荤当(t菕ng)閭勫彲浠ョ敤浜庡緸妤�(y猫)浜哄摗鐨勫煿瑷�(x霉n)銆傛湰绯荤当(t菕ng)浠LC鐐烘牳蹇冿紝鐢辩偖鐪兼娓�(c猫)闆昏矾銆侀浕闆风鏂瑰悜妾㈡脯(c猫)闆昏矾銆佺偖娉ユ娓�(c猫)闆昏矾銆丳LC鍙婂叾鎿�(ku貌)灞曟ā濉婁互鍙奙CGS妯″绲勬垚銆傚湪瑭茬郴绲�(t菕ng)涓紝涓€鏂归潰涓嬩綅姗�(j墨)PLC灏囨娓�(c猫)闆昏矾閲囬泦鍒扮殑鍚勭ó鏁�(sh霉)鎿�(j霉)鍦ㄧ窔鍌抽€佺郸涓婁綅姗�(j墨)鐨凪CGS妯″锛孧CGS妯″浠跨湡鍑虹垎鐮寸挵(hu谩n)澧冿紝鐐虹垎鐮存柟妗堟焙绛栨彁渚涗緷鎿�(j霉)锛涘彟涓€鏂归潰涓婁綅姗�(j墨)閫氶亷MCGS妯″灏囩垎鐮存帶鍒跺懡浠ゅ拰瑾�(di脿o)搴﹀懡浠ゅ偝閫佺郸涓嬩綅姗�(j墨)锛屽煼(zh铆)琛岀垎鐮村嫊(d貌ng)浣滐紝寰炶€屽(sh铆)鐝�(xi脿n)鍦ㄤ豢鐪熺挵(hu谩n)澧冧腑姹虹瓥鍑烘渶浣崇殑鐖嗙牬鏂规
姹熻槆甯寖澶у(xu茅)
2021-04-11
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浜曚笅澶氬獟楂斾俊鎭湴闈㈤墕瀛旀帰娓�(c猫)鎶€琛�(sh霉)
瑗垮畨绉戞妧澶у(xu茅)鑷� 2009 骞撮枊濮嬪氨绀﹀北鎳�(y墨ng)鎬ユ晳鎻撮€氫俊鎶€琛�(sh霉)鍜岃鍌欒憲鎵嬮枊濮嬬爺绌讹紝鐝�(xi脿n)瑭叉垚鏋滅嵅涓湅鐓ょ偔宸ユキ(y猫)鍗�(xi茅)鏈�(hu矛)绉戞妧閫�(j矛n)姝ョ崕(ji菐ng)浜岀瓑鐛�(ji菐ng) 1 闋�(xi脿ng)锛屽(sh铆)鐢ㄦ柊鍨嬪皥鍒� 3 闋�(xi脿ng)锛岀櫦(f膩)琛ㄨ珫鏂� 6 绡囷紱鐮斿埗鎴愭灉閲濆皪(du矛)绀︿簳鎳�(y墨ng)鎬ユ晳鎻撮亷绋嬩腑鎵€閬囧埌鐨勫洶闆ｏ紝鐮旂┒鑸囬枊鐧�(f膩)鍏锋湁鍌宠几瑾為煶銆佽闋诲拰澶氱ó鐠�(hu谩n)澧冨弮鏁�(sh霉)鏁�(sh霉)鎿�(j霉)鐨勪簳涓嬪濯掗珨淇℃伅鍦伴潰閴嗗瓟鎺㈡脯(c猫)瑁濈疆锛屽(sh铆)鏅�(sh铆)銆佹簴(zh菙n)纰哄湴鎶婂彈鐏�(z膩i)閴嗗瓟涓強閫氶亷閴嗗瓟鎺㈡脯(c猫)鍒扮殑浜曞贩涓殑鍙楃伣(z膩i)淇℃伅鏅�(sh铆)瀵�(sh铆)鏅�(sh铆)鍌抽€佸埌鍦伴潰鏁戠伣(z膩i)鎸囨彯閮ㄥ強鍚勭礆(j铆)鏁戞彺鎸囨彯涓績锛岀偤鏁戠伣(z膩i)鎸囨彯鍝¤垏灏堝鎻愪緵婧�(zh菙n)纰哄彲闈犵殑鐏�(z膩i)鎯呬俊鎭紝閬�(d谩)鍒扮瀛�(xu茅)鍒跺畾鏁戠伣(z膩i)鏂规鐨勭洰鐨勯爡(xi脿ng)鐩爺绌舵垚鏋滅洰鍓嶆垚鍔熷緱瀹屾垚浜嗗娆＄う灞变簨鏁呮噳(y墨ng)鎬ユ晳鎻达紝骞剁偤鐓ょう浼佹キ(y猫)鎸藉洖宸ㄥぇ缍�(j墨ng)婵�(j矛)鎼嶅け锛屼繚闅滀簡寤ｅぇ鐓ょう浜曚笅宸ヤ綔浜哄摗鐨勪汉韬畨鍏紝妯圭珛浜嗚壇濂界殑鍦嬮殯褰㈣薄锛屽彇寰楃殑宸ㄥぇ鐨勭稉(j墨ng)婵�(j矛)鏁堢泭鍜岀ぞ鏈�(hu矛)鏁堢泭锛屾帹寤ｆ噳(y墨ng)鐢ㄥ墠鏅唬闂娿€�
瑗垮畨绉戞妧澶у(xu茅)
2021-04-11
浜曚笅娣峰嚌鍦熷埗鍌欒几閫佹(j墨)绲�
瑗垮畨绉戞妧澶у(xu茅)鐓ょう鏀(h霉)鐮旂櫦(f膩)涓績鐜嬫泬鍒╂暀鎺堝壍(chu脿ng)鏂板湗(tu谩n)闅�(du矛)澶氬勾寰炰簨浜曚笅鏀(h霉)鍙婅ō(sh猫)鍌欑爺绌讹紝闁嬬櫦(f膩)鍑轰簳涓嬫贩鍑濆湡鍒跺倷杓搁€佹(j墨)绲勶紝宸茬嵅寰�3闋�(xi脿ng)灏堝埄銆備簳涓嬫贩鍑濆湡鍒跺倷杓搁€佹(j墨)绲勫寘鎷埉鏉夸笂鏂欐(j墨)銆佹贩鍑濆湡鍒跺倷姗�(j墨)銆佺う鐢ㄦ贩鍑濆湡娉点€傛柦宸ュ伐钘濈偤锛氬湴闈㈡贩鍑濆湡鏀媽绔欐寜瑷�(sh猫)瑷�(j矛)閰嶅悎姣旀敧鎷屽ソ骞叉枡鍚庯紝閫氶亷鐒¤粚鑶犺吉杌婃垨搴曞嵏寮忕う杌婇亱(y霉n)杓歌嚦浜曚笅锛屾贩鍑濆湡骞叉枡鍗歌嚦鍒澘涓婃枡姗�(j墨)鐨勫埉鏉挎Ы鍏�(n猫i)锛屽埉鏉挎(j墨)閬�(y霉n)杞�(zhu菐n)灏囧共鏂欒几閫佽嚦娣峰嚌鍦熷埗鍌欐(j墨)鐨勬敧鎷屾Ы鍏�(n猫i)鍔犳按閫ｇ簩(x霉)鏀媽锛屾敧鎷屽ソ鐨勬繒鏂欐簻鍏ョう鐢ㄦ贩鍑濆湡娉垫枡鏂楀収(n猫i)瀵�(sh铆)鐝�(xi脿n)閬�(yu菐n)璺濋洟娉甸€併€傝┎濂楁(j墨)绲勭洰鍓嶅凡鍦ㄧ鏉辩叅鐐泦鍦�(tu谩n)鍏徃銆佺鑿鐓ら泦鍦�(tu谩n)銆佸北瑗挎綖瀹夌う妤�(y猫)闆嗗湗(tu谩n)銆佺鑿儚娴疯兘婧愰泦鍦�(tu谩n)銆侀櫆鐓ら泦鍦�(tu谩n)銆佺鐏泦鍦�(tu谩n)绛夊鍊�(g猫)鍠綅寰楀埌浜嗘噳(y墨ng)鐢ㄣ€�
瑗垮畨绉戞妧澶у(xu茅)
2021-04-11
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娌�浜曚笅娌夐爯(y霉)璀︽柟娉曞拰绯荤当(t菕ng)
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