浜哄伐鏅鸿兘钘ョ墿绡╅伕銆佽棩鐗╄ō(sh猫)瑷�(j矛)鍙婃瘨鎬ч爯(y霉)娓�绠楁硶
鏈垚鏋滈噰鐢ㄦ渶鏂扮殑娣卞害瀛�(xu茅)缈�(x铆)鍜屽垎瀛愭ā鎿畻娉曪紝绲�(ji茅)鍚堟柊涓€浠e垎瀛愮壒寰佸寲鏂规硶锛岄枊鐧�(f膩)浜嗗绋▓(j矛)绠楁(j墨)妯″瀷锛屽彲鐢ㄤ簬钘ョ墿闁嬬櫦(f膩)涓殑澶氬€�(g猫)闅庢锛岀偤钘ョ墿鐨勫揩閫熻ō(sh猫)瑷�(j矛)闁嬬櫦(f膩)鎻愪緵涓€鍊�(g猫)瀹屾暣鐨勫熀浜庝汉宸ユ櫤鑳界殑瑙f焙鏂规銆傛垚鏋滐細1.钘ョ墿姣掓€ч爯(y霉)娓柟娉曪細鍌崇当(t菕ng)鐨勫寲鍚堢墿姣掓€ф娓妧琛�(sh霉)涓€鑸渶瑕佷娇鐢ㄧ敓鍖栬│椹�(y脿n)銆佺窗(x矛)鑳炲(sh铆)椹�(y脿n)銆佺敋鑷冲嫊(d貌ng)鐗╂ā鍨嬶紝閫欎簺鏂规硶涓嶅儏鑰楄不(f猫i)澶ч噺鏅�(sh铆)闁擄紝鑰屼笖鎴愭湰寰堥珮銆備娇鐢ㄨ▓(j矛)绠楁ā鍨嬮€�(j矛n)琛屾湁姗�(j墨)鍖栧悎鐗╃殑姣掓€ч爯(y霉)娓紝鎵€闇€鎶曞叆杓冨皯锛屼絾鐢�(ch菐n)鍑哄法澶с€傜壒鍒ユ槸鍩轰簬鍖栧悎鐗╃殑鐗╃悊鍖栧(xu茅)鍜岀祼(ji茅)妲�(g貌u)鐗规€х殑瑷�(j矛)绠楁ā鍨嬶紝鐢氳嚦鑳藉鍦ㄥ寲鍚堢墿鍚堟垚涔嬪墠灏卞皪(du矛)鍏堕€�(j矛n)琛岄爯(y霉)娓紝澶уぇ鎻愰珮浜嗘晥鐜囷紝浣垮叾瓒婁締瓒婂彈鍒版杩庛€傚湪閫�(j矛n)琛岄珨澶栧拰楂斿収(n猫i)瑭﹂(y脿n)涔嬪墠鍏堜娇鐢ㄨ▓(j矛)绠楁(j墨)妯″瀷灏�(du矛)鍖栧悎鐗╅€�(j矛n)琛屽ぇ瑕�(gu墨)妯$殑姣掓€х閬革紝鑳藉鏇村ソ鍦拌В姹哄€欓伕钘ョ墿鍏锋湁姣掓€х殑鍟忛銆傛垜鍊戝缓绔嬩簡涓€濂楁柊鐨勫熀浜庡绋垎瀛愭寚绱嬪拰姗�(j墨)鍣ㄥ(xu茅)缈�(x铆)绠楁硶鐨勫寲鍚堢墿姣掓€ч爯(y霉)娓泦鎴愬(xu茅)缈�(x铆)绠楁硶锛岄亱(y霉n)鐢ㄦ闆嗘垚瀛�(xu茅)缈�(x铆)绠楁硶寤虹珛浜嗘柊鐨勬湁姗�(j墨)鍖栧悎鐗╄嚧鐧屾€с€佽嚧绐佽畩鎬у拰鑲濇瘨鎬ч爯(y霉)娓ā鍨嬨€傛垜鍊戝垎鍒ュ缓绔嬩簡鍚嶇偤CarcinoPred-EL (http://112.126.70.33/toxicity/CarcinoPred-EL/, 鑷寸檶鎬ч爯(y霉)娓�)銆丮utagenPred-EL (http://112.126.70.33/toxicity/MutagenPred-EL/, 鑷寸獊璁婃€ч爯(y霉)娓�)銆丩iverToxPred-EL (http://112.126.70.33/toxicity/LiverToxPred-EL/, 鑲濇瘨鎬ч爯(y霉)娓�)鐨勯爯(y霉)娓湇鍕�(w霉)鍣紝閫欎簺鏈嶅嫏(w霉)鍣ㄨ兘澶�?y脿n)妲璋滃挍宄佲敂顝冨挐笑顜兼啲鑾稿康A(y霉)娓妧琛�(sh霉)鏈嶅嫏(w霉)銆傝嚜2017骞存湇鍕�(w霉)鍣ㄧ櫦(f膩)琛ㄨ捣锛屾垜鍊戝凡鐐哄湅鍏�(n猫i)澶栬棩鐗╁垎瀛愯ō(sh猫)瑷�(j矛)鐮旂┒鑰呮彁渚涗簡5000澶氭鍏辫▓(j矛)瓒呴亷20澶氳惉鍊�(g猫)鍖栧悎鐗╃殑姣掓€ч爯(y霉)娓湇鍕�(w霉)銆傚湪鏈夋(j墨)鍖栧悎鐗╂瘨鎬ч爯(y霉)娓爺绌舵柟鍚戯紝鎴戝€戜富瑕佸畬鎴愪簡鍖栧悎鐗╃殑绱�(x矛)鑳炴瘨鎬с€佸績鑷熸瘨鎬с€佺敓娈栨瘨鎬с€佽鑵﹀睆闅滈€忛亷鎬с€佹按鐢熺敓鐗╂瘨鎬ч爯(y霉)娓ā鍨嬶紝浠ュ強绯栧翱鐥呮棭鏈熺鏌ユā鍨嬬殑闁嬬櫦(f膩)锛屾鍦ㄩ€�(j矛n)琛孭450閰堕樆婊姂鎬ч爯(y霉)娓ā鍨嬨€佸熀浜庡湒绁炵稉(j墨ng)缍�(w菐ng)绲�(lu貌)鐨勬瘨鎬ч爯(y霉)娓畻娉曠爺绌躲€佸熀浜庡垎瀛愬皪(du矛)鎺ョ殑鍖栧悎鐗╂瘨鎬ч爯(y霉)娓爺绌剁瓑銆傜浉闂�(gu膩n)鐮旂┒鎴愭灉宸茬櫦(f膩)琛ㄥ绡囧(xu茅)琛�(sh霉)璜栨枃锛圸hang L., et al. Scientific Reports, 2017, 7: 2118. WOS琚紩娆℃暩(sh霉)80锛孍SI 1%楂樿寮曡珫鏂囷紱Ai H., et al. Toxicological Sciences, 2018, 165: 100-107锛沋in Z., et al. Journal of Applied Toxicology. 2019, 39(10): 1366-1377锛汚i H., et al. Ecotoxicology and Environmental Safety. 2019, 179: 71-78锛汱iu M., et al. Toxicology Letters. 2020, 332: 88-96锛汧eng H., et al. Toxicology Letters. 2021, 340: 4-14锛汱i S. et al. Interdisciplinary Sciences: Computational Life Sciences. 2021, 13: 25-33.锛夎嚧鐧屾€ч爯(y霉)娓湇鍕�(w霉)鍣ㄩ闋佽嚧鐧屾€ч爯(y霉)娓祼(ji茅)鏋滈爜鐩搁棞(gu膩n)缍滆堪灏�(du矛)鏈湇鍕�(w霉)鍣ㄧ殑浠嬬垂RF-hERG-Score闋�(y霉)娓棩鐗╁紩璧风殑hERG鐩搁棞(gu膩n)蹇冭嚐姣掓€�2.钘ョ墿瑷�(sh猫)瑷�(j矛)鏂规硶锛氬湪瑷�(j矛)绠楁(j墨)涓婂皪(du矛)钘ョ墿闈堕粸(di菐n)鍜岃棩鐗╁垎瀛愮殑绲�(ji茅)妲�(g貌u)鍜屾椿鎬у缓妯★紝瑷�(j矛)绠楄棩鐗╄垏闈堕粸(di菐n)涔嬮枔鐨勭浉浜掍綔鐢ㄩ棞(gu膩n)绯伙紝寰炶€岃ō(sh猫)瑷�(j矛)鍑哄叿鏈夋不鐧備綔鐢ㄧ殑钘ョ墿銆傝▓(j矛)绠楁(j墨)杓斿姪钘ョ墿瑷�(sh猫)瑷�(j矛)鍙互鐐鸿棩鐗╄ō(sh猫)瑷�(j矛)鍚勯殠娈电殑瀵�(sh铆)椹�(y脿n)鏂规鎻愪緵鏈夋剰缇╃殑鎸囧皫(d菐o)锛屾笡灏戦渶瑕侀€氶亷瀵�(sh铆)椹�(y脿n)瑭�(p铆ng)浼扮殑鍊欓伕钘ョ墿鐨勬暩(sh霉)閲忥紝寰炶€屽姞蹇柊钘ョ爺鐧�(f膩)閫熷害銆傛垜鍊戞噳(y墨ng)鐢ㄥ垎瀛愬皪(du矛)鎺ャ€佸垎瀛愬嫊(d貌ng)鍔涘(xu茅)妯℃摤銆佽嚜鐢辫兘瑷�(j矛)绠椼€佹(j墨)鍣ㄥ(xu茅)缈�(x铆)绛夋柟娉曠爺绌舵祦鎰熺梾姣掔瓑閲嶈鐤剧梾鐨勮▓(j矛)绠楁(j墨)杓斿姪钘ョ墿瑷�(sh猫)瑷�(j矛)銆佸苟闁嬬櫦(f膩)鏇存湁鏁堢殑瑷�(j矛)绠楁(j墨)杓斿姪钘ョ墿瑷�(sh猫)瑷�(j矛)鏂规硶銆傚湪瑷�(j矛)绠楁(j墨)杓斿姪钘ョ墿瑷�(sh猫)瑷�(j矛)鐮旂┒鎴戝€戜富瑕佸畬鎴愪簡娴佹劅鐥呮瘨M2璩�(zh矛)瀛愰€氶亾铔嬬櫧鎶戝埗鍔戣櫅鎿閬告柟娉曠爺绌讹紝姝e湪閫�(j矛n)琛屽厛灏�(d菐o)鍖栧悎鐗╃敓鎴愭ā鍨嬬爺绌躲€佸熀浜庢(j墨)鍣ㄥ(xu茅)缈�(x铆)鐨勮櫅鎿閬告墦鍒嗗嚱鏁�(sh霉)绠楁硶闁嬬櫦(f膩)銆丼ARS-CoV-2鐥呮瘨S铔嬬櫧鑸囧彈楂旂浉浜掍綔鐢ㄥ強钘ョ墿瑷�(sh猫)瑷�(j矛)鐮旂┒銆傜壒鐣版€ч噸鎵撳垎鍑芥暩(sh霉)椤憲铏涙摤绡╅伕鎬ц兘椤憲杓冮珮绡╅伕鍑哄叐鍊�(g猫)鍊欓伕鎶戝埗鍔�3.钘ョ墿闈堕粸(di菐n)璀�(sh铆)鍒ユ柟娉曪細闀烽潪绶ㄧ⒓RNA锛坙ncRNA锛夋槸涓€绋暦搴﹀湪200nt鑷�100,000nt涔嬮枔鐨勯潪绶ㄧ⒓RNA锛屾槸杞�(zhu菐n)閷勭墿鐨勪富瑕佹垚鍒嗐€傜爺绌惰〃鏄巐ncRNA鍦ㄨū澶氱敓鐗╁(xu茅)鍜岀梾鐞嗗(xu茅)閬庣▼涓捣钁楅噸瑕佷綔鐢ㄣ€俵ncRNA璧蜂綔鐢ㄧ殑閲嶈閫斿緫鏄垏鍏堕澏铔嬬櫧绲�(ji茅)鍚堛€俵ncRNA-铔嬬櫧璩�(zh矛)鐩镐簰浣滅敤鐨勫(sh铆)椹�(y脿n)鐮旂┒闇€瑕佸ぇ閲忚硣婧愩€傜疮绌嶇殑瀵�(sh铆)椹�(y脿n)鏁�(sh霉)鎿�(j霉)浣垮緱閫氶亷瑷�(j矛)绠楁柟娉曢爯(y霉)娓琹ncRNA-铔嬬櫧璩�(zh矛)鐩镐簰浣滅敤鎴愮偤鍙兘銆傛垜鍊戜娇鐢ㄥ悇绋暩(sh霉)瀛�(xu茅)寤烘ā鍜屾(j墨)鍣ㄥ(xu茅)缈�(x铆)鏂规硶闁嬬櫦(f膩)浜嗗咕绋敤浜庨爯(y霉)娓琹ncRNA-铔嬬櫧璩�(zh矛)鐩镐簰浣滅敤鐨勬柊妯″瀷銆傞€欎簺妯″瀷鍛藉悕鐐猴細RWLPAP锛堥毃姗�(j墨)娓歌蛋锛夛紝LPI-NRLMF锛堥劙鍩熸鍓囧寲閭忚集鐭╅櫍鍒嗚В锛夛紝IRWNRLPI锛堥泦鎴愰毃姗�(j墨)娓歌蛋鍜岄劙鍩熻(gu墨)鍓囧寲Logistic鐭╅櫍鍒嗚В锛夛紝LPI-BNPRA锛堥洐鍚戠恫(w菐ng)绲�(lu貌)鎶曞奖鎺ㄨ枽绠楁硶锛夛紝LPI-ETSLP锛堝熀浜庣壒寰佸€艰畩鎻涚殑鍗婄洠(ji膩n)鐫i張璺爯(y霉)娓級锛孒LPI-Ensemble锛堥泦鎴愬(xu茅)缈�(x铆)锛夈€傚湪浜ゅ弶椹�(y脿n)璀変腑锛屾垜鍊戠殑妯″瀷鐛插緱浜嗚純濂界殑闋�(y霉)娓€ц兘銆俵ncRNA-铔嬬櫧璩�(zh矛)鐩镐簰浣滅敤闋�(y霉)娓ā鍨嬬殑鎬ц兘姣旇純lncRNA-铔嬬櫧璩�(zh矛)鐩镐簰浣滅敤闋�(y霉)娓湇鍕�(w霉)鍣ㄧ浉闂�(gu膩n)杌熶欢钁椾綔娆�(qu谩n)锛�
閬煎澶у(xu茅)
2021-04-10