钁′含濞变箰鍦�-瀵岀泩濞变箰鍦哄紑鎴�

1 鎴愭灉绨′粙鑱氬悎鐗╅浕瑙ｈ唱(zh矛)鐢变簬鍏锋湁璩�(zh矛)杓�銆佺矘褰堟€уソ浠ュ強鎴愯啘鎬уソ绛夊劒(y艒u)榛�(di菐n)锛屽挨鍏堕仼鍚堜綔鐐洪嫲闆绘睜鐨勯浕瑙ｈ唱(zh矛)鏉愭枡銆傝仛姘т箼鐑紙 PEO锛夌敱浜庡叿鏈夋槗浜庨洟瀛愬偝灏�(d菐o)鐨勭祼(ji茅)妲�(g貌u)鐗瑰緛鑰屽倷鍙楅棞(gu膩n)娉�锛岀劧鑰岀敱浜� PEO鑸囧牽閲戝爆楣藉舰鎴愮殑鑱氬悎鐗╅浕瑙ｈ唱(zh矛)鍦ㄥ婧檪(sh铆)鏈夎純楂樼殑绲�(ji茅)鏅剁浉锛屾墍褰㈡垚鐨勯浕瑙ｈ唱(zh矛)涔熷彧鑳藉湪楂樻韩涓嬫墠鑳戒娇鐢�锛屽洜姝ゅ(sh铆)闅涙噳(y墨ng)鐢ㄥ彈鍒伴檺鍒躲€傚父鐢ㄤ締闄嶄綆 PEO 绲�(ji茅)鏅跺害鐨勬柟娉曟槸鍔犲叆鏈夋(j墨)娑查珨澧炲鍔�锛屾恫楂斿濉戝姂鐨勫姞鍏ラ洊鐒舵彁楂樹簡鑱氬悎鐗╅浕瑙ｈ唱(zh矛)鐨勯洟瀛愰浕灏�(d菐o)鐜�锛屼絾鍚屾檪(sh铆)涔熺牬澹炰簡闆昏В璩�(zh矛)鐨勬(j墨)姊版€ц兘浠ュ強澧炲姞浜嗗叾鑸囬嫲璨�(f霉)妤垫潗鏂欑殑鍙嶆噳(y墨ng)娲绘€э紝闄嶄綆浜嗛浕姹犲＝鍛�銆備竴鍊嬮噸瑕佺殑瓒ㄥ嫝鏄櫦(f膩)灞曞叏鍥烘厠(t脿i)鑱氬悎鐗╅浕瑙ｈ唱(zh矛)锛屼互鍙栦唬鐩墠鐨勫惈娑查珨鐨勮仛鍚堢墿闆昏В璩�(zh矛)銆�2 鎳�(y墨ng)鐢ㄨ鏄庢湰鐧�(f膩)鏄庢彁渚涗簡涓€绋嫲闆绘睜鐢ㄥ叡鑱氱墿鍩鸿仛鍚堢墿闆昏В璩�(zh矛)鏉愭枡锛屽叾鍚湁鍏辫仛鐗╁熀楂斿拰鍫块噾灞菇锛屾墍杩板叡鑱氱墿鍩洪珨鏄敱姘у寲涔欑儻鍠厓鍜屾哀鍖栦笝鐑柈鍏冪祫鎴�銆傛湰鐧�(f膩)鏄庨倓鎻愪緵浜嗗惈鎵€杩拌仛鍚堢墿闆昏В璩�(zh矛)鏉愭枡鐨勫京(f霉)鍚堥浕瑙ｈ唱(zh矛)鑶滃強鍏跺埗鍌欐柟娉�锛屾湰鐧�(f膩)鏄庢墍杩扮殑閶伴浕姹犵敤鍏辫仛鐗╁熀鑱氬悎鐗╅浕瑙ｈ唱(zh矛)鏉愭枡锛岄噰鐢ㄥ叡鑱氱墿浣滅偤鍩洪珨鏉愭枡锛岄€氶亷绨″柈鐨勬憾娑叉締閼勬硶鍒跺倷鎴愯仛鍚堢墿闆昏В璩�(zh矛)鏉愭枡锛屽苟閲囩敤娴告场鏂规硶瀵�(sh铆)鐝�(xi脿n)娲绘€ц仛鍚堢墿闆昏В璩�(zh矛)鏉愭枡鑸囬珮鍒嗗瓙闅旇啘鏉愭枡鐨勫京(f霉)鍚�銆傛湰鐧�(f膩)鏄庣殑鑱氬悎鐗╅浕瑙ｈ唱(zh矛)鏉愭枡涓嶅惈鏈夋(j墨)娑叉厠(t脿i)闆昏В璩�(zh矛)锛屼笉鍙噧锛屼笖鑸囧偝绲�(t菕ng)鐨� PEO 鍩鸿仛鍚堢墿闆昏В璩�(zh矛)鐩告瘮锛岄浕灏�(d菐o)鐜囨槑椤彁楂橈紝姗�(j墨)姊版€ц兘濂�锛� 鍙互闃叉鐔卞け鎺с€�3 鏁堢泭鍒嗘瀽寤鸿ō(sh猫)骞寸敘(ch菐n) 1500 鍣哥殑浜屾閶伴浕姹犵敤寰�(f霉)鍚堝瀷鍏ㄥ浐鎱�(t脿i)鑱氬悎鐗╅浕浠嬭唱(zh矛)鏉愭枡鐢熺敘(ch菐n)绶氾紝 闋�(xi脿ng)鐩附鎶曡硣5000 钀厓銆�4 鍚堜綔鏂瑰紡鍚堜綔銆佹妧琛�(sh霉)鎻愪緵鏂瑰崰鎶€琛�(sh霉)鑲�銆�

銆愮櫦(f膩) 鏄庝汉銆戦儹鐩涳紱娈甸噾寤掞紱閷㈠ぇ鐟�锛涘妯硅槶銆愭憳    瑕併€戞湰鐧�(f膩)鏄庡叕闁嬩簡涓€绋ぇ妫楄憠娲绘€ф彁鍙栫墿鍙婂叾鍦ㄥ埗鍌欓槻娌昏倽鎼嶅偡钘ョ墿鎴栦繚鍋ュ搧涓殑鎳�(y墨ng)鐢ㄣ€傛湰鐧�(f膩)鏄庨娆￠噰鐢ㄥぇ瀛旀ü鑴傝€﹀悎鑱氶叞鑳烘ü鑴傦紝鐒跺悗閫氶亷鍒跺倷娑茬浉鍒跺倷澶ф钁夌簿鍒舵彁鍙栫墿锛岃純鍌崇当(t菕ng)鐨勫垎闆㈢磾鍖栨柟娉曞垎闆㈡晥鐜囨洿楂�锛屼笖鍒嗛洟寰楀埌鐨勬椿鎬ф垚鍒嗗惈閲忛珮锛岀敓鐗╂椿鎬у挤(qi谩ng)锛屽畨鍏ㄦ€ч珮銆傜稉(j墨ng)瀵�(sh铆)椹�(y脿n)鐮旂┒琛ㄦ槑锛屽ぇ妫楄憠鎻愬彇鐗╁彲椤憲闄嶄綆CCl4銆丏-GalN鍜屼箼閱囨墍鑷磋倽鎼嶅偡妯″瀷灏忛紶琛€娓匒LT銆丄ST娲绘€у強鑲濈祫绻擬DA鍚噺锛屽寮�(qi谩ng)鑲濊嚐SOD娲绘€�锛屽皪鑲濇悕鍌峰叿鏈夊緢濂界殑闃叉不鍔熸晥銆傚洜姝ゅぇ妫楄憠鍙婂ぇ妫楄憠鎻愬彇鐗╂湁鏈涢枊鐧�(f膩)鎴愮偤鏂颁竴浠ｅ畨鍏ㄦ湁鏁堬紝鐢ㄤ簬闃叉不鑲濇悕鍌风殑钘ョ墿鎴栦繚鍋ュ搧锛屽悓鏅�(sh铆)涔熺偤澶ф钁夊虎妫勮硣婧愯畩寤㈢偤瀵跺強妫楁ü璩囨簮缍滃悎鍒╃敤鎻愪緵浜嗛€斿緫銆�

銆愮櫦(f膩) 鏄� 浜恒€戦儹绔嬬憢锛涗粯寤锋槑锛涙湵鑿槑锛涙湵鑿棴锛涘嫉鍟熸槬锛涘妷宄�锛涘嫉鍋夈€愭憳瑕併€戞湰鐧�(f膩)鏄庢彁渚涗竴绋不鐧傚績鑵﹁绠＄柧鐥呯殑钘ョ墿绲勫悎鐗�銆佸埗鍌欐柟娉曞強鍏惰唱(zh矛)閲忔帶鍒舵柟娉�锛屾秹鍙婂埗钘ラ牁(l菒ng)鍩�銆傛墍杩版不鐧傚績鑵﹁绠＄柧鐥呯殑钘ョ墿绲勫悎鐗�锛岀敱涓嬭堪閲嶉噺閰嶆瘮鐨勪腑钘ュ師鏂欏埗鎴愶細鍦伴緧30~50浠�銆佸叏铦�15~25浠藉拰姘磋洯30~50浠�銆傚叾鍒跺倷鏂规硶锛屽寘鎷涓嬫椹燂細灏囧湴榫嶇矖绮�銆佸叏铦庡強姘磋洯绮楃矇娣峰悎鍧囧嫽锛屽姞姘存蹈娉�锛屽皣钘ユ潗閫ｅ悓娴告场娑插姞鍏ョ矇纰庢(j墨)閫�(j矛n)琛屾繒娉曠矇纰庯紝闆㈠績锛屽彇涓婃竻娑蹭綔閲囩敤涓┖绾栫董鑶滈亷婵�锛屽彇绮楁彁鍙栨恫涓垎瀛愰噺鑼冨湇鐐�9~120KDa鐨勭祫鍒嗗嵆寰楁墍杩版不鐧傚績鑵﹁绠＄柧鐥呯殑钘ョ墿绲勫悎鐗�銆傛湰鐧�(f膩)鏄庤棩鐗╃祫鍚堢墿锛屽幓闄や簡钘ユ潗涓共鎿捐棩鏁堢殑闆滆唱(zh矛)锛屾墍浠ユ姉琛€鏍撴柟闈㈢殑钘ユ晥杓冨偝绲�(t菕ng)钘ョ墿椤憲澧炲挤(qi谩ng)锛屼笖鑳介’钁楁笡灏戞湇鐢ㄥ姂閲�锛屽嵒骞舵湭妾㈡脯鍒版瘨鎬с€�

  瑭查爡(xi脿ng)鐩湪鍒╃敤寰敓鐗╃窗(x矛)鑳炰腑鐨勯叾閫�(j矛n)琛岀敓鐗╁偓鍖栫敓鐢�(ch菐n)鎵嬪緛鎬у寲鍚堢墿鏅�(sh铆)閲囩敤閬庣▼闆嗘垚鎶€琛�(sh霉)锛岄€氶亷鍒嗛洟鑸囧弽鎳�(y墨ng)鑰﹀悎鍎�(y艒u)鍖栫敓鐢�(ch菐n)閬庣▼锛屽ぇ澶ф彁楂樹簡鐢熺墿鍌寲杞�(zhu菐n)鍖栭珨绯荤殑鏁堢巼锛岄檷浣庣敓鐢�(ch菐n)鎴愭湰锛岀啊鍖栫敓鐢�(ch菐n)閬庣▼锛屽舰鎴愬叿鏈夎嚜涓荤煡璀樼敘(ch菐n)娆�(qu谩n)鐨凩-铇嬫灉閰歌垏L-涓欐皑閰稿壍(chu脿ng)鏂扮殑鐢熺敘(ch菐n)宸ヨ棟娴佺▼銆傞噰鐢ㄥ弽鎳�(y墨ng)鑸囧垎闆㈣€﹀悎鎶€琛�(sh霉)锛屽皪绯荤当(t菕ng)鏁撮珨閬庣▼鐨勯泦鎴愬劒(y艒u)鍖�锛屽彲閫氶亷鍒嗛洟鑰﹀悎瑙ｆ焙鍙嶆噳(y墨ng)閬庣▼杞�(zhu菐n)鍖栫巼浣庣殑鍟忛锛岄€�

鏈櫦(f膩)鏄庢秹鍙婄磵绫崇矑瀛愬埗鍌欓牁(l菒ng)鍩燂紝鍏枊浜嗕竴绋憾娑叉硶鍚堟垚宓屾鑱氬悎鐗╂帴鏋濈磵绫充簩姘у寲纭呯殑鏂规硶锛岄€氶亷灏嶇磵绫崇矑瀛愬強鍏舵噳(y墨ng)鐢ㄩ渶姹傞€�(j矛n)琛屾暣楂旇ō(sh猫)瑷�(j矛)锛岄€氶亷灏嶇磵绫充簩姘у寲纭呰〃闈㈡椿鍖栨敼鎬э紝鎺ユ灊涓婂叿鏈変笉鍚屾€ц唱(zh矛)鐨勫绲勫厓绶氭€ц仛閰張娈碉紝骞跺紩鍏ヤ笉鍚屾€ц唱(zh矛)绶氭€ц仛閰暦鍒嗗瓙閺堬紝寰楀埌鍏锋湁鐗规畩琛ㄩ潰绲�(ji茅)妲�(g貌u)鐨勬敼鎬х磵绫充簩姘у寲纭咃紱缍�(j墨ng)閬庤〃闈㈢壒娈婄祼(ji茅)妲�(g貌u)淇＞鍚�锛屽舰鎴愨€滄湁姗�(j墨)鑳￠爤鈥濆寘瑕嗙殑绱嶇背浜屾哀鍖栫绮掑瓙锛岃┎绋磵绫崇矑瀛愯垏澶у鏁�(sh霉)妯硅剛鍩洪珨鏈夊緢濂界殑鐩稿鎬�锛屽叾涓仛閰張娈靛彲浠ョ祼(ji茅)鏅舵垚鏍�锛岄€�(j矛n)鑰屽憟鐝�(xi脿n)鍑哄皪绶氭€ц仛閰ü鑴傚熀楂旂殑鍎�(y艒u)鐣扮殑鎴愭牳瑾樺皫(d菐o)鏁堟噳(y墨ng)銆傜磵绫充簩姘у寲纭呭湪濉戞枡銆佹鑶�銆佺簴缍�銆佹秱鏂�銆佺敓鐗╂妧琛�(sh霉)绛夐牁(l菒ng)鍩熸湁钁楀唬娉涚殑鎳�(y墨ng)鐢�銆�

鍏枊浜嗕竴绋寲鍚堢墿2?缇ュ熀?3?姘�?5?纭濆熀?1?鑻熀涓侀叜鍙婂叾鍒跺倷鏂规硶鍜岃静(n贸ng)鐢ㄧ敓鐗╂椿鎬с€傚湪鍙嶆噳(y墨ng)鍣ㄥ収(n猫i)鍔犲叆纭濋吀銆佷箼閰愬強鐢查唶锛屾敧鎷屼竴娈垫檪(sh铆)闁撳悗灏囧弽鎳�(y墨ng)娑查檷婧嚦0鍒�20鈩冿紝鍔犲叆2?缇ュ熀?3?姘�?1?鑻熀涓侀叜锛屽弽鎳�(y墨ng)涓€娈垫檪(sh铆)闁撳悜鍙嶆噳(y墨ng)娣峰悎鐗╁姞鍏ユ按锛屽啀鍔犲叆涔欓吀涔欓叝钀冨彇澶氭锛屽緸鏈夋(j墨)鐩哥嵅寰楃洰妯�(bi膩o)鍖栧悎鐗�銆傝┎鍖栧悎鐗╁皪铇嬫灉鑵愮垱銆佺櫧鑿滅伆闇夈€佹煈姗樼偔鐤姐€佹鑺辨灟钀庛€佸皬楹ュ叏铦曠瓑妞嶇墿鐥呭師鑿屽叿鏈夎純楂樼殑鎶戝埗浣滅敤銆�

鐮旂櫦(f膩)闅庢/n鏈櫦(f膩)鏄庡叕闁嬩簡鍏锋姉鑵槫娲绘€х殑缇婃瘺鐢剧兎鍨嬩笁钀滃寲鍚堢墿鍙婂叾鍒跺倷鏂规硶鍜屾噳(y墨ng)鐢�銆傚叾鍒跺倷鏂规硶鍖呮嫭锛氬埗鍌欓潏鑺濆瓙鑿岀挡楂旀垨瀛愬(sh铆)楂旂殑涔欓唶鎻愬彇鐗╋紱灏囬潏鑺濆瓙鑿岀挡楂旀垨瀛愬(sh铆)楂旂殑涔欓唶鎻愬彇鐗╂竻鑶忎互姘村垎鏁ｅ悗锛岀敤鐭虫补閱氬弽寰�(f霉)钀冨彇锛屽啀鐢ㄤ箼閰镐箼閰悆鍙栵紝寰椾箼閰镐箼閰彁鍙栫墿锛涘皣涔欓吀涔欓叝鎻愬彇鐗╅€氶亷姝ｇ浉銆佸弽鐩镐互鍙婂嚌鑶犳煴灞ゆ瀽鍙嶅京(f霉)鍒嗛洟寰楀埌涓夐儴鍒嗭紱鐢ㄥ埗鍌欓珮鏁堟恫鐩歌壊璀滐紝鍒嗗垾浠ヤ箼鑵堬紞鐢查唶锛嶆按楂旂郴娲楄劔锛屾敹闆嗙浉鎳�(y墨ng)绲勫垎鍚�锛屾笡澹撹捀骞插悗鍗冲緱銆傛湰鐧�(f膩)鏄庡緸闈堣姖瀛愬(sh铆)楂旀垨鐧�(f膩)閰佃弻绲查珨涓垎闆㈠緱鍒帮紩绋柊鐨勭緤姣涚斁鐑疯鐢熺墿锛岀稉(j墨ng)鐢熺墿娲绘€ц⿻鍍�(ji脿)锛屾湰鐧�(f膩)鏄庢柊鍒嗛洟鐨勶紩绋緤姣涚斁鐑疯鐢熺墿鑳藉鏈夋晥鎶�

鏈櫦(f膩)鏄庢秹鍙婂寲瀛�(xu茅)鍌寲鍔戝埗鍌欐妧琛�(sh霉)锛屾棬鍦ㄦ彁渚涗竴绋敤浜庢隘浠ｆ彯鐧�(f膩)鎬ф湁姗�(j墨)鐗╀綆婧偓鍖栫噧鐕掔殑鍌寲鍔戝強鍒跺倷鏂规硶銆傝┎鍌寲鍔戞槸浠ノ�?Al2O3椤嗙矑鐐鸿級楂�锛屼互NM?RMO?Co3O4鐐烘椿鎬х祫鍒嗭紱鍏朵腑锛孯MO?Co3O4鍗犲偓鍖栧姂閲嶉噺鐨�5锝�15锛�锛孨M鍗犲偓鍖栧姂閲嶉噺鐨�0.01锛咃綖0.2锛�锛屼綑閲忕偤纬?Al2O3椤嗙矑锛涙墍杩癛MO鐐虹█鍦熼噾灞哀鍖栫墿CeO2銆乑rO2銆丩a2O3銆丯d2O3銆乊2O3涓殑涓€绋垨骞剧ó锛孨M鐐鸿泊閲戝爆Pd銆丳t銆丷u銆丷h涓殑涓€绋垨骞剧ó銆傛湰鐧�(f膩)鏄庢彁渚涚殑鍌寲鍔戝叿鏈夊埗鍌欏伐钘濈啊鍠�銆佸児(ji脿)鏍间綆寤夈€佸偓鍖栨椿鎬ч珮銆佹姉姘腑姣掕兘鍔涘挤(qi谩ng)銆佸＝鍛介暦绛夊劒(y艒u)榛�(di菐n)銆傞噰鐢ㄨ┎鍌寲鍔戯紝鍙互鍦ㄤ綆婧┖姘ｇ挵(hu谩n)澧冧腑锛岄暦鏅�(sh铆)闁撶┅(w臎n)瀹氬湴灏囧惈姘彯鐧�(f膩)鎬ф湁姗�(j墨)鐗╄綁(zhu菐n)鍖栫偤CO2鍜孒Cl锛屼笖鎶€琛�(sh霉)璺窔鏂逛究瀵�(sh铆)鐢紝鍙唬娉涙噳(y墨ng)鐢ㄤ簬宸ユキ(y猫)鍚隘鏈夋(j墨)寤㈡埃鐨勬不鐞嗐€�

01. 鎴愭灉绨′粙 涓澅鍛煎惛缍滃悎寰佸啝鐙€鐥呮瘨锛圡ERS-CoV锛夋槸2012骞村湪涓澅鍦板崁(q奴)棣栧厛鐧�(f膩)鐝�(xi脿n)鐨勪竴绋柊鍨嬪啝鐙€鐥呮瘨锛岃垏鍤�(y谩n)閲嶆€ユ€у懠鍚哥稖鍚堝緛鍐犵媭鐥呮瘨锛圫ARS-CoV锛夊悓灞簬尾鍐犵媭鐥呮瘨锛岃兘澶犲紩鐧�(f膩)鍤�(y谩n)閲嶇殑浜洪鍛煎惛绯荤当(t菕ng)鐤剧梾銆傛摎(j霉)涓栫晫琛�(w猫i)鐢熺祫绻旂殑鏈€鏂扮当(t菕ng)瑷�(j矛)琛ㄦ槑锛孧ERS-CoV宸查€犳垚鍏ㄧ悆27鍊嬪湅瀹�2428渚嬫劅鏌擄紝鑷存鐜囬珮閬�(d谩)35%銆� MERS-CoV琛ㄩ潰鍒虹獊铔嬬櫧锛圫pike锛夎泲鐧芥槸鐥呮瘨椤嗙矑鑸囩窗(x矛)鑳炲彈楂斾簩鑲藉熀鑲介叾4锛圖PP4锛変綔鐢ㄧ殑闂�(gu膩n)閸佃泲鐧�锛屼篃鏄疢ERS-CoV鐤嫍鑸囦繚璀�(h霉)鎬у柈鍏嬮殕鎶楅珨鐮旂┒鐨勭啽闁€闈堕粸(di菐n)銆傛湰闋�(xi脿ng)鐩湗(tu谩n)闅�(du矛)鍦ㄩ澏鍚戝埡绐佽泲鐧界殑楂樻椿鎬т腑鍜屾姉楂旂閬�銆侀憭瀹�銆佸垎瀛愮祼(ji茅)妲�(g貌u)鐮旂┒涓彇寰椾簡涓€绯诲垪绐佺牬銆傛湰鍦�(tu谩n)闅�(du矛)鍦ㄥ湅闅涗笂棣栨壒鍫�(b脿o)閬撲簡鍏╂牚浜烘簮MERS-CoV涓拰鎶楅珨MERS-4鑸嘙ERS-27锛屽畠鍊戝潎鑳介珮鏁堟姂鍒跺亣鐥呮瘨鑸囨椿鐥呮瘨灏嶉珨澶栧煿椁�(y菐ng)绱�(x矛)鑳炵殑渚垫煋锛屽湪鍕曠墿妯″瀷涓篃椤ず浜嗗緢濂界殑淇濊(h霉)浣滅敤銆傝┎鍦�(tu谩n)闅�(du矛)閭勭稖鍚堥亱(y霉n)鐢ㄧ祼(ji茅)妲�(g貌u)鐢熺墿瀛�(xu茅)銆佺敓鐗╁寲瀛�(xu茅)浠ュ強鐥呮瘨瀛�(xu茅)鐮旂┒鏂规硶闂℃槑浜嗛€欏叐鏍姉楂旇瓨鍒pike鍙楅珨绲�(ji茅)鍚堢祼(ji茅)妲�(g貌u)鍩燂紙RBD锛夌殑涓嶅悓浣嶉粸(di菐n)锛屽苟闃绘柗Spike鑸囧彈楂擠PP4鐨勭祼(ji茅)鍚�銆� 鏈爡(xi脿ng)鐩湗(tu谩n)闅�(du矛)閭勫埄鐢ㄤ竴绋█鏈夐粦鐚╃尒鑵虹梾姣扐dC68鐐鸿級楂�锛屾惌杓塎ERS-CoV琛ㄩ潰鍏ㄩ暦鐨凷pike铔嬬櫧锛屽湪杞�(zhu菐n)鍩哄洜灏忛紶锛坔DPP4-KI锛夋ā鍨嬩腑锛屼竴娆℃淮榧诲厤鐤嵆鍙獦灏�(d菐o)鐢�(ch菐n)鐢熼暦鏈熶繚璀�(h霉)鎬у厤鐤弽鎳�(y墨ng)锛屽苟瀹屽叏闋�(y霉)闃插皬榧犳劅鏌撴垨闄嶄綆鎰熸煋鍚庣殑鐤剧梾閫�(j矛n)灞曢€熷害銆傝В姹轰簡鐩墠鐮旂櫦(f膩)鐨凪ERS-CoV鐤嫍澶у闇€瑕侀€�(j矛n)琛屽娆″厤鐤敞灏勭殑寰�(f霉)闆滅▼搴忓晱椤�銆傞€�(j矛n)涓€姝ョ殑鎶楅珨鍒嗘瀽琛ㄦ槑锛屽厤鐤嫊鐗╄娓呬腑鍚湁寤ｈ瓬楂樻淮搴﹂嚌灏峈BD鐨勫鍏嬮殕鍜屽柈鍏嬮殕涓拰鎶楅珨锛岃兘澶犳湁鏁堥樆鏂风梾姣掕垏鍙楅珨DPP4鐨勭祼(ji茅)鍚堬紝寰炶€岃В鏋愪簡鍏堕暦鏈熶繚璀�(h霉)鎬у厤鐤弽鎳�(y墨ng)鐨勫垎瀛愬熀绀�(ch菙)鍜屾(j墨)鍒�锛岀偤鐤嫍涓嬩竴闅庢閫�(j矛n)鍏ュぇ鍕曠墿妯″瀷鍜屼汉楂旇嚚搴婅│椹�(y脿n)鍋氬ソ浜嗘簴(zh菙n)鍌�銆�                        MERS-CoV鍙婂叾鐩搁棞(gu膩n)涓拰鎶楅珨鍜岀柅鑻楃爺绌舵檪(sh铆)闁撹桓AdC68-S閲嶇祫鐤嫍鍦╤DPP4-KI杞�(zhu菐n)鍩哄洜灏忛紶妯″瀷涓婄殑淇濊(h霉)鏁堟灉02. 鎳�(y墨ng)鐢ㄥ墠鏅� 鏈爡(xi脿ng)鎴愭灉鍙噳(y墨ng)鐢ㄤ簬娌荤檪鎴栭爯(y霉)闃蹭腑鏉卞懠鍚哥稖鍚堝緛鍐犵媭鐥呮瘨鐨勬姉楂旇棩鐗╁強鐤嫍鍊欓伕鐗�銆�03. 鐭ヨ瓨鐢�(ch菐n)娆�(qu谩n) 鏈爡(xi脿ng)鎴愭灉宸茬敵璜�4闋�(xi脿ng)鐧�(f膩)鏄庡皥鍒�锛屽叾涓�3闋�(xi脿ng)宸叉巿娆�(qu谩n)銆�04. 鍦�(tu谩n)闅�(du矛)浠嬬垂 鏈爡(xi脿ng)鐩湗(tu谩n)闅�(du矛)鐢辩敓鍛藉(xu茅)闄㈠(sh铆)椹�(y脿n)瀹よ垏閱�(y墨)瀛�(xu茅)闄㈠(sh铆)椹�(y脿n)瀹よ伅(li谩n)鍚堢祫鎴愶紝鍏╀綅瀵�(sh铆)椹�(y脿n)瀹よ矤(f霉)璨�(z茅)浜哄垎鍒ョ偤娓呰彲澶у(xu茅)鐢熷懡瀛�(xu茅)闄㈠拰閱�(y墨)瀛�(xu茅)闄㈡暀鎺�銆佸崥澹敓灏�(d菐o)甯紝涓昏鐮旂┒鏂瑰悜鍒嗗垾鐐虹祼(ji茅)妲�(g貌u)鐢熺墿瀛�(xu茅)鑸囩梾姣掑(xu茅)锛屽凡鐧�(f膩)琛ㄥ湅鍏�(n猫i)澶栭珮姘村钩瀛�(xu茅)琛�(sh霉)璜栨枃鏁�(sh霉)鍗佺瘒锛岃伅(li谩n)鍚堢敵璜嬪皥鍒�4闋�(xi脿ng)銆�05.鍚堜綔鏂瑰紡 鎶€琛�(sh霉)瑷卞彲銆�06.鑱�(li谩n)绯绘柟寮� 閮电锛歾hangxinrui@tsinghua.edu.cn

銆愮櫦(f膩) 鏄� 浜恒€戦儹鐩涳紱娈甸噾寤�锛涢將澶х憢锛涘妯硅槶 銆愭憳瑕併€� 鏈櫦(f膩)鏄庡叕闁嬩簡涓€绋ぇ妫楄憠娲绘€ф彁鍙栫墿鍙婂叾鍦ㄥ埗鍌欓槻娌昏倽鎼嶅偡钘ョ墿鎴栦繚鍋ュ搧涓殑鎳�(y墨ng)鐢�銆傛湰鐧�(f膩)鏄庨娆￠噰鐢ㄥぇ瀛旀ü鑴傝€﹀悎鑱氶叞鑳烘ü鑴�锛岀劧鍚庨€氶亷鍒跺倷娑茬浉鍒跺倷澶ф钁夌簿鍒舵彁鍙栫墿锛岃純鍌崇当(t菕ng)鐨勫垎闆㈢磾鍖栨柟娉曞垎闆㈡晥鐜囨洿楂�锛屼笖鍒嗛洟寰楀埌鐨勬椿鎬ф垚鍒嗗惈閲忛珮锛岀敓鐗╂椿鎬у挤(qi谩ng)锛屽畨鍏ㄦ€ч珮銆傜稉(j墨ng)瀵�(sh铆)椹�(y脿n)鐮旂┒琛ㄦ槑锛屽ぇ妫楄憠鎻愬彇鐗╁彲椤憲闄嶄綆CCl4銆丏-GalN鍜屼箼閱囨墍鑷磋倽鎼嶅偡妯″瀷灏忛紶琛€娓匒LT銆丄ST娲绘€у強鑲濈祫绻擬DA鍚噺锛屽寮�(qi谩ng)鑲濊嚐SOD娲绘€�锛屽皪鑲濇悕鍌峰叿鏈夊緢濂界殑闃叉不鍔熸晥銆傚洜姝ゅぇ妫楄憠鍙婂ぇ妫楄憠鎻愬彇鐗╂湁鏈涢枊鐧�(f膩)鎴愮偤鏂颁竴浠ｅ畨鍏ㄦ湁鏁堬紝鐢ㄤ簬闃叉不鑲濇悕鍌风殑钘ョ墿鎴栦繚鍋ュ搧锛屽悓鏅�(sh铆)涔熺偤澶ф钁夊虎妫勮硣婧愯畩寤㈢偤瀵跺強妫楁ü璩囨簮缍滃悎鍒╃敤鎻愪緵浜嗛€斿緫銆�