闋呯洰鎴愭灉/绨′粙:
11鏈�4鏃ワ紝澶╂触澶у鐢熷懡绉戝瀛搁櫌鐜嬫郡瑾查绲勫湪Journal of Virology鍦ㄧ窔鐧艰〃浜嗘渶鏂扮爺绌舵垚鏋滐紝璜栨枃椤岀洰鐐衡€淓nterovirus D68 Protease 2AproTargets TRAF3 to Subvert Host Innate Immune Responses鈥濄€� 鑵搁亾鐥呮瘨EV-D68锛圗nterovirus D68锛夊彲寮曡捣鍏稿瀷涓婂懠鍚搁亾鎰熸煋鐧ョ媭锛屽悓鏅傞倓鏈冭獦鐧间腑妯炵缍撶郴绲辩柧鐥咃紝濡傛€ユ€у紱绶╂€ч夯鐥瑰拰鎬ユ€х劇鍔涜剨楂撶値绛夈€傝繎骞翠締锛屾垜鍦嬪皪EV-D68鐨勬鍑虹巼閫愭几鍗囬珮锛屽瓨鍦ㄥぇ瑕忔ā鏆寸櫦鐨勯ⅷ闅€傝吀閬撶梾姣掔殑闈炵祼妲嬭泲鐧�2A铔嬬櫧閰讹紙2Apro锛夋槸鍗斿姪鐥呮瘨閫冮伩瀹夸富澶╃劧鍏嶇柅鐨勯棞閸佃泲鐧姐€� 鐜嬫郡鍦橀殜鐧肩従鍦ㄦ劅鏌揈V-D68鍚庯紝2Apro鍙’钁楁姂鍒禨EV瑾樺皫鐨勨厾鍨嬪共鎿剧礌鍙嶆噳銆傞€蹭竴姝ョ爺绌剁櫦鐝撅紝2Apro鑳藉鍒嗗垾鍦℉eLa鍜孒EK293T绱拌優涓垏鍓睺RAF3鐨凜绔崁鍩燂紝鍒囧壊鍚庡緱鍒扮殑姊濆付澶у皬鐐�40 kDa宸﹀彸銆傚悓鏅傦紝2Apro涓107浣嶆皑鍩洪吀鐨勫崐鑳辨皑閰歌涓欐皑閰稿彇浠e悗锛屽柂澶卞皪TRAF3鐨勫垏鍓叉椿鎬э紝鑰孴RAF3涓462浣嶆皑鍩洪吀鐢樻皑閰哥獊璁婄偤涓欐皑閰告檪锛岃〃鐝惧嚭灏�2Apro鍒囧壊鐨勬姉鎬с€� 鏈爺绌剁櫦鐝句簡EV-D68鐨�2Apro鑳藉鍒囧壊瀹夸富澶╃劧鍏嶇柅閫氳矾涓殑TRAF3铔嬬櫧锛屽緸鑰岀牬澹炲涓荤殑鍏堝ぉ鍏嶇柅鎳夌瓟锛屽苟灏�2Apro鍜孴RAF3鍒囧壊鐨勫叿楂斾綅榛炲拰姗熷埗鍋氫簡瑭崇窗鍫遍亾銆�
鎺冪⒓闂滄敞锛屾煡鐪嬫洿澶氱鎶€鎴愭灉